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Palbociclib hydrochloride

CAS No. 827022-32-2

Palbociclib hydrochloride ( PD-0332991 hydrochloride;PD0332991 hydrochloride;PD 0332991 hydrochloride )

Catalog No. M16069 CAS No. 827022-32-2

A potent and selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM; no inhibition for CDK2A (IC50>5 uM); inhibits MDA-MB453 cells with IC50 of 0.16 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Palbociclib hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM; no inhibition for CDK2A (IC50>5 uM); inhibits MDA-MB453 cells with IC50 of 0.16 uM.
  • Description
    A potent and selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM; no inhibition for CDK2A (IC50>5 uM); inhibits MDA-MB453 cells with IC50 of 0.16 uM; shows antiproliferative effect against retinoblastoma (Rb)-positive tumor cells in vitro and reduces the phospho-Ser780/Ser795 on the Rb protein; orally bioavailable.Breast Cancer Approved
  • Synonyms
    PD-0332991 hydrochloride;PD0332991 hydrochloride;PD 0332991 hydrochloride
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK2/CyclinA;CDK2/CyclinE2;CDK4/CyclinD1;CDK4/CyclinD3;CDK6/CyclinD2
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    827022-32-2
  • Formula Weight
    483.99
  • Molecular Formula
    C24H30ClN7O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 6 mg/mL (Need ultrasonic or warming)
  • SMILES
    Cl.CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N3CCNCC3)N=C2N(C2CCCC2)C1=O
  • Chemical Name
    Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Toogood PL, et al. J Med Chem. 2005 Apr 7;48(7):2388-406.
2. Fry DW, et al. Mol Cancer Ther. 2004 Nov;3(11):1427-38.
3. Baughn LB, et al. Cancer Res. 2006 Aug 1;66(15):7661-7.
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